N-heterocyclic carbene-catalyzed cross-coupling of aromatic aldehydes with activated alkyl halides
| Title | N-heterocyclic carbene-catalyzed cross-coupling of aromatic aldehydes with activated alkyl halides |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Padmanaban, M, Biju, AT, Glorius, F |
| Journal | Organic Letters |
| Volume | 13 |
| Issue | 1 |
| Pagination | 98–101 |
| Date Published | NOV |
| Abstract | N-Heterocyclic carbene-catalyzed umpolung of aldehydes followed by their interception with diarylbromomethanes has been reported. This conceptually novel transition-metal-free cross-coupling of aldehydes with alkyl halides works well at low catalyst loadings and under mild reaction conditions leading to the formation of diaryl acetophenone derivatives in good yields. In addition, α-halo ketones and esters can also be used as aldehyde reaction partners. |
| DOI | 10.1021/ol102626p |
| Funding Agency | Council of Scientific & Industrial Research (CSIR) - India |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.17 |
Divison category:
Organic Chemistry