TY - JOUR T1 - N-heterocyclic carbene-catalyzed cross-coupling of aromatic aldehydes with activated alkyl halides JF - Organic Letters Y1 - 2011 A1 - Padmanaban, Mohan A1 - Biju, Akkattu T. A1 - Glorius, Frank AB -

N-Heterocyclic carbene-catalyzed umpolung of aldehydes followed by their interception with diarylbromomethanes has been reported. This conceptually novel transition-metal-free cross-coupling of aldehydes with alkyl halides works well at low catalyst loadings and under mild reaction conditions leading to the formation of diaryl acetophenone derivatives in good yields. In addition, α-halo ketones and esters can also be used as aldehyde reaction partners.

VL - 13 IS - 1 U2 -

Council of Scientific & Industrial Research (CSIR) - India

U3 - Foreign U4 - 6.17 ER -