01060nas a2200157 4500008004100000245010300041210006900144260000800213300001300221490000700234520046900241100002200710700002200732700001900754856012900773 2011 eng d00aN-heterocyclic carbene-catalyzed cross-coupling of aromatic aldehydes with activated alkyl halides0 aNheterocyclic carbenecatalyzed crosscoupling of aromatic aldehyd cNOV a98–1010 v133 a
N-Heterocyclic carbene-catalyzed umpolung of aldehydes followed by their interception with diarylbromomethanes has been reported. This conceptually novel transition-metal-free cross-coupling of aldehydes with alkyl halides works well at low catalyst loadings and under mild reaction conditions leading to the formation of diaryl acetophenone derivatives in good yields. In addition, α-halo ketones and esters can also be used as aldehyde reaction partners.
1 aPadmanaban, Mohan1 aBiju, Akkattu, T.1 aGlorius, Frank uhttp://library.ncl.res.in/content/n-heterocyclic-carbene-catalyzed-cross-coupling-aromatic-aldehydes-activated-alkyl-halides