Desymmetrization approach to the enantiopure syn/anti-1,5-diols via hydrolytic kinetic resolution (hkr) of functionalized meso-bis-epoxides: further elaboration to syn/syn-1,3,5-triols and application to the formal synthesis of cryptocarya diacetate
| Title | Desymmetrization approach to the enantiopure syn/anti-1,5-diols via hydrolytic kinetic resolution (hkr) of functionalized meso-bis-epoxides: further elaboration to syn/syn-1,3,5-triols and application to the formal synthesis of cryptocarya diacetate |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Kumar, P, Chowdhury, PSarathi, Pandey, M |
| Journal | Advanced Synthesis & Catalysis |
| Volume | 355 |
| Issue | 9 |
| Pagination | 1719-1723 |
| Date Published | JUN |
| ISSN | 1615-4150 |
| Keywords | bis-epoxides, cryptocarya diacetate, desymmetrization, stereoselective reduction, synthetic methods |
| Abstract | A new approach has been developed for the synthesis of enantiopure syn/anti-1,5-diols by desymmetrization of functionalized meso-bis-epoxides using hydrolytic kinetic resolution (HKR). The usage of this protocol was demonstrated by converting syn-1,5-diols into syn/syn-1,3,5-triols and its subseqent application to the formal synthesis of cryptocarya diacetate. |
| DOI | 10.1002/adsc.201300098 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 5.542 |
Divison category:
Organic Chemistry