In situ, on-resin synthesis of 8-Br/NH2 adeninyl peptide nucleic acid (PNA) oligomers and complementation studies with DNA
| Title | In situ, on-resin synthesis of 8-Br/NH2 adeninyl peptide nucleic acid (PNA) oligomers and complementation studies with DNA |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Vysabhattar, R, Ganesh, KN |
| Journal | Tetrahedron Letters |
| Volume | 51 |
| Issue | 50 |
| Pagination | 6560-6564 |
| Date Published | DEC |
| ISSN | 0040-4039 |
| Abstract | A new, novel and efficient in situ synthesis of 8-aminoadeninyl PNA oligomers from corresponding 8-bromoadeninyl PNA oligomers is reported. The study of hybridisation properties of (8-Br/8-NH2) PNA oligomers with cDNA reveals substitution-site dependent stabilization of derived triplexes and duplexes. (C) 2010 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2010.10.040 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.618 |
Divison category:
Organic Chemistry