%0 Journal Article %J Tetrahedron Letters %D 2010 %T In situ, on-resin synthesis of 8-Br/NH2 adeninyl peptide nucleic acid (PNA) oligomers and complementation studies with DNA %A Vysabhattar, Raman %A Ganesh, Krishna N. %X

A new, novel and efficient in situ synthesis of 8-aminoadeninyl PNA oligomers from corresponding 8-bromoadeninyl PNA oligomers is reported. The study of hybridisation properties of (8-Br/8-NH2) PNA oligomers with cDNA reveals substitution-site dependent stabilization of derived triplexes and duplexes. (C) 2010 Elsevier Ltd. All rights reserved.

%B Tetrahedron Letters %I PERGAMON-ELSEVIER SCIENCE LTD %C THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND %V 51 %P 6560-6564 %8 DEC %G eng %N 50 %3 Foreign %4 2.618 %R 10.1016/j.tetlet.2010.10.040