One-step synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines and their use in the synthesis of highly functionalized 2,3,5,6,7-and 2,3,4,5,7-substituted indoles
| Title | One-step synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines and their use in the synthesis of highly functionalized 2,3,5,6,7-and 2,3,4,5,7-substituted indoles |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Sawargave, SP, Kudale, AS, Deore, JV, Bhosale, DS, Divse, JM, Chavan, SP, Borate, HB |
| Journal | Tetrahedron Letters |
| Volume | 52 |
| Issue | 42 |
| Pagination | 5491-5493 |
| Date Published | OCT |
| ISSN | 0040-4039 |
| Keywords | aldehydes, Dicyanoanilines, indoles, Malononitrile |
| Abstract | A three-component, one-step method for the synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines involving reaction of alkyl aldehyde, malononitrile and aryl aldehyde in presence of morpholine is reported. Highly functionalized 2,3,5,6,7- and 2,3,4,5,7-substituted indoles were prepared from these dicyanoanilines by reaction with ethyl bromoacetate. These substituted dicyanoanilines and indoles have a potential to be converted into various other compounds taking advantage of various functional groups present in these molecules. (C) 2011 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2011.08.064 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.683 |
Divison category:
Organic Chemistry