TY - JOUR T1 - One-step synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines and their use in the synthesis of highly functionalized 2,3,5,6,7-and 2,3,4,5,7-substituted indoles JF - Tetrahedron Letters Y1 - 2011 A1 - Sawargave, Sangmeshwer P. A1 - Kudale, Ananada S. A1 - Deore, Jaydeep V. A1 - Bhosale, Dattatry S. A1 - Divse, Jaisingh M. A1 - Chavan, Subhash P. A1 - Borate, Hanumant B. KW - aldehydes KW - Dicyanoanilines KW - indoles KW - Malononitrile AB -

A three-component, one-step method for the synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines involving reaction of alkyl aldehyde, malononitrile and aryl aldehyde in presence of morpholine is reported. Highly functionalized 2,3,5,6,7- and 2,3,4,5,7-substituted indoles were prepared from these dicyanoanilines by reaction with ethyl bromoacetate. These substituted dicyanoanilines and indoles have a potential to be converted into various other compounds taking advantage of various functional groups present in these molecules. (C) 2011 Elsevier Ltd. All rights reserved.

PB - PERGAMON-ELSEVIER SCIENCE LTD CY - THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND VL - 52 IS - 42 U3 - Foreign U4 - 2.683 ER -