01625nas a2200265 4500008004100000022001400041245016100055210006900216260010600285300001400391490000700405520058200412653001400994653002001008653001201028653001801040100003101058700002401089700002301113700002601136700002401162700002401186700002501210856012401235 2011 eng d a0040-403900aOne-step synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines and their use in the synthesis of highly functionalized 2,3,5,6,7-and 2,3,4,5,7-substituted indoles0 aOnestep synthesis of 4alkyl3aryl26dicyanoanilines and their use aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT a5491-54930 v523 a
A three-component, one-step method for the synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines involving reaction of alkyl aldehyde, malononitrile and aryl aldehyde in presence of morpholine is reported. Highly functionalized 2,3,5,6,7- and 2,3,4,5,7-substituted indoles were prepared from these dicyanoanilines by reaction with ethyl bromoacetate. These substituted dicyanoanilines and indoles have a potential to be converted into various other compounds taking advantage of various functional groups present in these molecules. (C) 2011 Elsevier Ltd. All rights reserved.
10aaldehydes10aDicyanoanilines10aindoles10aMalononitrile1 aSawargave, Sangmeshwer, P.1 aKudale, Ananada, S.1 aDeore, Jaydeep, V.1 aBhosale, Dattatry, S.1 aDivse, Jaisingh, M.1 aChavan, Subhash, P.1 aBorate, Hanumant, B. uhttp://library.ncl.res.in/content/one-step-synthesis-4-alkyl-3-aryl-26-dicyanoanilines-and-their-use-synthesis-highly-0