Intermolecular N-heterocyclic carbene-catalyzed hydroacylation of arynes
| Title | Intermolecular N-heterocyclic carbene-catalyzed hydroacylation of arynes |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Biju, AT, Glorius, F |
| Journal | Angewandte Chemie-International Edition |
| Volume | 49 |
| Issue | 50 |
| Pagination | 9761–9764 |
| Date Published | DEC |
| Abstract | A formal introduction: The conceptually new N-heterocyclic carbene catalyzed formal insertion of arynes into the Cformyl[BOND]H bond of aldehydes demonstrates the compatibility of nucleophilic NHCs with electrophilic arynes. This NHC-catalyzed hydroacylation of arynes allows the conversion of aliphatic, α,β-unsaturated, and aromatic aldehydes into aryl ketones; 27 examples and a preliminary mechanistic investigation are provided. |
| DOI | 10.1002/anie.201005490 |
| Funding Agency | Council of Scientific & Industrial Research (CSIR) - India |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 12.730 |
Divison category:
Organic Chemistry