00960nas a2200145 4500008004100000245007700041210006900118260000800187300001600195490000700211520044700218100002200665700001900687856010800706 2010 eng d00aIntermolecular N-heterocyclic carbene-catalyzed hydroacylation of arynes0 aIntermolecular Nheterocyclic carbenecatalyzed hydroacylation of cDEC a9761–97640 v493 a
A formal introduction: The conceptually new N-heterocyclic carbene catalyzed formal insertion of arynes into the Cformyl[BOND]H bond of aldehydes demonstrates the compatibility of nucleophilic NHCs with electrophilic arynes. This NHC-catalyzed hydroacylation of arynes allows the conversion of aliphatic, α,β-unsaturated, and aromatic aldehydes into aryl ketones; 27 examples and a preliminary mechanistic investigation are provided.
1 aBiju, Akkattu, T.1 aGlorius, Frank uhttp://library.ncl.res.in/content/intermolecular-n-heterocyclic-carbene-catalyzed-hydroacylation-arynes