%0 Journal Article %J Angewandte Chemie-International Edition %D 2010 %T Intermolecular N-heterocyclic carbene-catalyzed hydroacylation of arynes %A Biju, Akkattu T. %A Glorius, Frank %X

A formal introduction: The conceptually new N-heterocyclic carbene catalyzed formal insertion of arynes into the Cformyl[BOND]H bond of aldehydes demonstrates the compatibility of nucleophilic NHCs with electrophilic arynes. This NHC-catalyzed hydroacylation of arynes allows the conversion of aliphatic, α,β-unsaturated, and aromatic aldehydes into aryl ketones; 27 examples and a preliminary mechanistic investigation are provided.

%B Angewandte Chemie-International Edition %V 49 %P 9761–9764 %8 DEC %G eng %N 50 %2

Council of Scientific & Industrial Research (CSIR) - India

%3 Foreign %4 12.730 %R 10.1002/anie.201005490