ChIP-Seq data analysis: identification of protein-DNA binding sites with SISSRs peak-finder

TitleChIP-Seq data analysis: identification of protein-DNA binding sites with SISSRs peak-finder
Publication TypeJournal Article
Year of Publication2012
AuthorsNarlikar, L, Jothi, R
JournalMethods in molecular biology
Volume802
Pagination305-22
Date PublishedJAN
AbstractProtein-DNA interactions play key roles in determining gene-expression programs during cellular development and differentiation. Chromatin immunoprecipitation (ChIP) is the most widely used assay for probing such interactions. With recent advances in sequencing technology, ChIP-Seq, an approach that combines ChIP and next-generation parallel sequencing is fast becoming the method of choice for mapping protein-DNA interactions on a genome-wide scale. Here, we briefly review the ChIP-Seq approach for mapping protein-DNA interactions and describe the use of the SISSRs peak-finder, a software tool for precise identification of protein-DNA binding sites from sequencing data generated using ChIP-Seq.
DOI10.1007/978-1-61779-400-1_20
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)1.69
Divison category: 
Chemical Engineering & Process Development