ChIP-Seq data analysis: identification of protein-DNA binding sites with SISSRs peak-finder
| Title | ChIP-Seq data analysis: identification of protein-DNA binding sites with SISSRs peak-finder |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Narlikar, L, Jothi, R |
| Journal | Methods in molecular biology |
| Volume | 802 |
| Pagination | 305-22 |
| Date Published | JAN |
| Abstract | Protein-DNA interactions play key roles in determining gene-expression programs during cellular development and differentiation. Chromatin immunoprecipitation (ChIP) is the most widely used assay for probing such interactions. With recent advances in sequencing technology, ChIP-Seq, an approach that combines ChIP and next-generation parallel sequencing is fast becoming the method of choice for mapping protein-DNA interactions on a genome-wide scale. Here, we briefly review the ChIP-Seq approach for mapping protein-DNA interactions and describe the use of the SISSRs peak-finder, a software tool for precise identification of protein-DNA binding sites from sequencing data generated using ChIP-Seq. |
| DOI | 10.1007/978-1-61779-400-1_20 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.69 |
Divison category:
Chemical Engineering & Process Development