01248nas a2200145   4500008004100000245009600041210006900137260000800206300001100214490000800225520070800233100002400941700001600965856012100981       2012                        eng d00aChIP-Seq data analysis: identification of protein-DNA binding sites with SISSRs peak-finder0 aChIPSeq data analysis identification of proteinDNA binding sites  cJAN  a305-220 v8023 aProtein-DNA interactions play key roles in determining gene-expression programs during cellular development and differentiation. Chromatin immunoprecipitation (ChIP) is the most widely used assay for probing such interactions. With recent advances in sequencing technology, ChIP-Seq, an approach that combines ChIP and next-generation parallel sequencing is fast becoming the method of choice for mapping protein-DNA interactions on a genome-wide scale. Here, we briefly review the ChIP-Seq approach for mapping protein-DNA interactions and describe the use of the SISSRs peak-finder, a software tool for precise identification of protein-DNA binding sites from sequencing data generated using ChIP-Seq.1 aNarlikar, Leelavati1 aJothi, Raja  uhttp://library.ncl.res.in/content/chip-seq-data-analysis-identification-protein-dna-binding-sites-sissrs-peak-finder