Catalytic asymmetric transfer hydrogenation of ketones using [Ru(p-cymene)Cl-2](2) with chiral amino alcohol ligands

TitleCatalytic asymmetric transfer hydrogenation of ketones using [Ru(p-cymene)Cl-2](2) with chiral amino alcohol ligands
Publication TypeJournal Article
Year of Publication2010
AuthorsDeshpande, SH, Kelkar, AA, Gonnade, RG, Shingote, SK, Chaudhari, RV
JournalCatalysis Letters
Volume138
Issue3-4
Pagination231-238
Date PublishedSEP
ISSN1011-372X
KeywordsAmino alcohol ligand, Asymmetric transfer hydrogenation, Ketones, Ru catalyst
Abstract

Catalytic asymmetric transfer hydrogenation of aromatic alkyl ketones has been investigated using [Ru(p-cymene)Cl-2](2) and new derivatives of beta-amino alcohols synthesized from (S)-(-)-lactic acid and mandelic acid as ligands. Chiral secondary alcohols were obtained with good to excellent conversion (60-90%) and moderate to good enantioselectivities (40-86%). Asymmetric transfer hydrogenation of ketones has been investigated using [Ru(p-cymene)Cl-2](2) and beta-amino alcohols synthesized from (S)-(-)-lactic acid and Mandelic acid as ligands. Chiral secondary alcohols were obtained with good to excellent conversion (60-90%) and moderate to good enantioselectivities (40-86%).
DOI10.1007/s10562-010-0408-y
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)1.907
Divison category: 
Center for Material Characterization (CMC)
Chemical Engineering & Process Development