Diastereoselective synthesis of chiral 2,3-disubstituted lndolines via formal [3+2]-cycloaddition of arynes with gamma-amino-alpha,beta-unsaturated esters
| Title | Diastereoselective synthesis of chiral 2,3-disubstituted lndolines via formal [3+2]-cycloaddition of arynes with gamma-amino-alpha,beta-unsaturated esters |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Aher, RD, Suryavanshi, GM, Sudalai, A |
| Journal | Journal of Organic Chemistry |
| Volume | 82 |
| Start Page | 5940-5946 |
| Issue | 11 |
| Pagination | 5940-5946 |
| Date Published | JUN |
| ISSN | 0022-3263 |
| Abstract | A one step formal [3+2]-annulation protocol for the synthesis of 2,3-disubstituted indolines is described. The in situ generated aryne acts as a two-atom component, and gamma-amino-alpha,beta-unsaturated esters acting as a three-atom component to construct indoline units in a highly regio- and diastereoselective manner with yields ranging from 63 to 80%. |
| DOI | 10.1021/acs.joc.7b00439 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.785 |
Divison category:
Chemical Engineering & Process Development