Metalloantitubercular compounds part 3: synthesis, crystal structure, spectroscopy, electrochemistry and antimycobacterial activity of the copper(II) ciproploxacin (cfH) complex and its phenanthroline adduct
| Title | Metalloantitubercular compounds part 3: synthesis, crystal structure, spectroscopy, electrochemistry and antimycobacterial activity of the copper(II) ciproploxacin (cfH) complex and its phenanthroline adduct |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Saha, DK, Patitungkho, S, Padhye, S, Deobagkar, DN, Ozarkar, A, Bhadbhade, MM, Gonnade, RG |
| Journal | Transition Metal Chemistry |
| Volume | 30 |
| Issue | 3 |
| Pagination | 334-340 |
| Date Published | APR |
| Type of Article | Article |
| ISSN | 0340-4285 |
| Abstract | The X-ray crystal structures of two ciprofloxacin compounds, viz. [Cu(cfH)(2)(Cl)(2)] (.) 2MeOH (.) 6H2O (2) and [Cu(cfH)(phen)Cl]BF4 (.) 4H(2)O (3) are reported. Complex ( 2) has a distorted octahedral geometry, whereas for the nitrogen adduct (3) a distorted square-pyramidal geometry is seen. Significant enhancement in the antimycobacterial activity of the copper conjugates correlates with their copper redox couples (Cu2+/Cu+) probably due to its relevance to intracellular accumulations and subsequent role in generating oxidative stress. |
| DOI | 10.1007/s11243-004-5861-2 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.465 |
Divison category:
Center for Material Characterization (CMC)
Physical and Materials Chemistry