01463nas a2200217 4500008004100000022001400041245021200055210006900267260007400336300001200410490000700422520055700429100001700986700002001003700001501023700002201038700001601060700002501076700002401101856012001125 2005 eng d a0340-428500aMetalloantitubercular compounds part 3: synthesis, crystal structure, spectroscopy, electrochemistry and antimycobacterial activity of the copper(II) ciproploxacin (cfH) complex and its phenanthroline adduct0 aMetalloantitubercular compounds part 3 synthesis crystal structu aVAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDSbSPRINGERcAPR a334-3400 v303 a
The X-ray crystal structures of two ciprofloxacin compounds, viz. [Cu(cfH)(2)(Cl)(2)] (.) 2MeOH (.) 6H2O (2) and [Cu(cfH)(phen)Cl]BF4 (.) 4H(2)O (3) are reported. Complex ( 2) has a distorted octahedral geometry, whereas for the nitrogen adduct (3) a distorted square-pyramidal geometry is seen. Significant enhancement in the antimycobacterial activity of the copper conjugates correlates with their copper redox couples (Cu2+/Cu+) probably due to its relevance to intracellular accumulations and subsequent role in generating oxidative stress.
1 aSaha, D., K.1 aPatitungkho, S.1 aPadhye, S.1 aDeobagkar, D., N.1 aOzarkar, A.1 aBhadbhade, Mohan, M.1 aGonnade, Rajesh, G. uhttp://library.ncl.res.in/content/metalloantitubercular-compounds-part-3-synthesis-crystal-structure-spectroscopy-1