Natural gum reduced/stabilized gold nanoparticles for drug delivery formulations
Title | Natural gum reduced/stabilized gold nanoparticles for drug delivery formulations |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Dhar, S, E. Reddy, M, Shiras, A, Pokharkar, V, Prasad, BLV |
Journal | Chemistry-A European Journal |
Volume | 14 |
Issue | 33 |
Pagination | 10244-10250 |
Date Published | OCT |
ISSN | 0947-6539 |
Keywords | Apoptosis, Cytotoxicity, drug delivery, Gold, Nanostructures, natural gums |
Abstract | ``Gellan Gum'', widely used in food and confectionary industry as a thickening and gelling agent, has been employed as a reducing and stabilizing agent for the synthesis of gold nanoparticles. These nanoparticles display greater stability to electrolyte addition and pH changes relative to the traditional citrate and borohydride reduced nanoparticles. Subsequently these have been used to load anthracycline ring antibiotic doxorubicin hydrochloride. The drug loaded on these nanoparticles showed enhanced cytotoxic effects on human glioma cell lines LN-18 and LN-229. |
DOI | 10.1002/chem.200801093 |
Type of Journal (Indian or Foreign) | Foreign |
Impact Factor (IF) | 5.476 |
Divison category:
Physical and Materials Chemistry