TY - JOUR T1 - Natural gum reduced/stabilized gold nanoparticles for drug delivery formulations JF - Chemistry-A European Journal Y1 - 2008 A1 - Dhar, Sheetal A1 - Reddy, E. Maheswara A1 - Shiras, Anjali A1 - Pokharkar, Varsha A1 - Bhagavatula L. V. Prasad KW - Apoptosis KW - Cytotoxicity KW - drug delivery KW - Gold KW - Nanostructures KW - natural gums AB -

``Gellan Gum'', widely used in food and confectionary industry as a thickening and gelling agent, has been employed as a reducing and stabilizing agent for the synthesis of gold nanoparticles. These nanoparticles display greater stability to electrolyte addition and pH changes relative to the traditional citrate and borohydride reduced nanoparticles. Subsequently these have been used to load anthracycline ring antibiotic doxorubicin hydrochloride. The drug loaded on these nanoparticles showed enhanced cytotoxic effects on human glioma cell lines LN-18 and LN-229.

PB - WILEY-V C H VERLAG GMBH CY - PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY VL - 14 IS - 33 U3 - Foreign U4 - 5.476 ER -