Efficient formal synthesis of (S)-dapoxetine from enantiopure 3-hydroxy azetidin-2-one
| Title | Efficient formal synthesis of (S)-dapoxetine from enantiopure 3-hydroxy azetidin-2-one |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Chincholkar, PM, Kale, AS, Gumaste, VK, Deshmukh, ARakeeb A |
| Journal | Tetrahedron |
| Volume | 65 |
| Issue | 12 |
| Pagination | 2605-2609 |
| Date Published | MAR |
| ISSN | 0040-4020 |
| Keywords | Azetidin 2 ones, beta-Lactams, Enantioselective synthesis, reduction, Staudinger reaction |
| Abstract | An efficient formal synthesis of S-(+) dapoxetine starting from 3-hydroxy azetidin-2-one is described. The intermediate (S)-3-(dimethyl amino)-3-phenylpropan-1-ol was synthesized in enantiopure form starting with 3-hydroxy azetidin-2-one in seven steps. (c) 2008 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tet.2008.11.042 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.011 |
Divison category:
Organic Chemistry