TY - JOUR T1 - Efficient formal synthesis of (S)-dapoxetine from enantiopure 3-hydroxy azetidin-2-one JF - Tetrahedron Y1 - 2009 A1 - Chincholkar, Pinak M. A1 - Kale, Ajaykumar S. A1 - Gumaste, Vikas K. A1 - Deshmukh, Abdul Rakeeb A. S. KW - Azetidin 2 ones KW - beta-Lactams KW - Enantioselective synthesis KW - reduction KW - Staudinger reaction AB -

An efficient formal synthesis of S-(+) dapoxetine starting from 3-hydroxy azetidin-2-one is described. The intermediate (S)-3-(dimethyl amino)-3-phenylpropan-1-ol was synthesized in enantiopure form starting with 3-hydroxy azetidin-2-one in seven steps. (c) 2008 Elsevier Ltd. All rights reserved.

PB - PERGAMON-ELSEVIER SCIENCE LTD CY - THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND VL - 65 IS - 12 U3 - Foreign U4 - 3.011 ER -