First asymmetric synthesis of the antiepileptic drug lacosamide (Vimpat (R)) based on a hydrolytic kinetic resolution strategy
| Title | First asymmetric synthesis of the antiepileptic drug lacosamide (Vimpat (R)) based on a hydrolytic kinetic resolution strategy |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Muthukrishnan, M, Mujahid, M, Sasikumar, M, Mujumdar, P |
| Journal | Tetrahedron-Asymmetry |
| Volume | 22 |
| Issue | 12 |
| Pagination | 1353-1357 |
| Date Published | JUN |
| ISSN | 0957-4166 |
| Abstract | An efficient asymmetric synthesis of the new antiepileptic drug, Lacosamide is described in high enantiopurity (>98% ee), using Jacobsen's hydrolytic kinetic resolution strategy as a key step. (C) 2011 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetasy.2011.07.024 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.67 |
Divison category:
Organic Chemistry