%0 Journal Article %J Tetrahedron-Asymmetry %D 2011 %T First asymmetric synthesis of the antiepileptic drug lacosamide (Vimpat (R)) based on a hydrolytic kinetic resolution strategy %A Muthukrishnan, Murugan %A Mujahid, Mohammad %A Sasikumar, M. %A Mujumdar, P. %X

An efficient asymmetric synthesis of the new antiepileptic drug, Lacosamide is described in high enantiopurity (>98% ee), using Jacobsen's hydrolytic kinetic resolution strategy as a key step. (C) 2011 Elsevier Ltd. All rights reserved.

%B Tetrahedron-Asymmetry %I PERGAMON-ELSEVIER SCIENCE LTD %C THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND %V 22 %P 1353-1357 %8 JUN %G eng %N 12 %3 Foreign %4 2.67 %R 10.1016/j.tetasy.2011.07.024