4(R/S)-Guanidinylprolyl collagen peptides: on-resin synthesis, complexation with plasmid DNA, and the role of peptides in enhancement of transfection
| Title | 4(R/S)-Guanidinylprolyl collagen peptides: on-resin synthesis, complexation with plasmid DNA, and the role of peptides in enhancement of transfection |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Nanda, M, Ganesh, KN |
| Journal | Journal of Organic Chemistry |
| Volume | 77 |
| Issue | 8 |
| Pagination | 4131-4135 |
| Date Published | APR |
| ISSN | 0022-3263 |
| Abstract | Chimeric collagen peptides containing cationic 4(R/S)-guanidinylproline are synthesized by in situ amidinylation of 4(R/S)-aminoproline residues. These peptides uniquely enhance the transfection efficiency of GFP-encoded plasmid DNA (pRmHa3-GFP) into cells through efficient DNA condensation resulting from nonspecific electrostatic interactions of cationic guanidino groups and localize in subcytoplasmic organelles. |
| DOI | 10.1021/jo300070p |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.564 |
Divison category:
Organic Chemistry