01131nas a2200157 4500008004100000022001400041245015400055210006900209260007100278300001400349490000700363520042900370100002100799700002400820856012900844 2012 eng d a0022-326300a4(R/S)-Guanidinylprolyl collagen peptides: on-resin synthesis, complexation with plasmid DNA, and the role of peptides in enhancement of transfection0 a4RSGuanidinylprolyl collagen peptides onresin synthesis complexa a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcAPR a4131-41350 v773 a
Chimeric collagen peptides containing cationic 4(R/S)-guanidinylproline are synthesized by in situ amidinylation of 4(R/S)-aminoproline residues. These peptides uniquely enhance the transfection efficiency of GFP-encoded plasmid DNA (pRmHa3-GFP) into cells through efficient DNA condensation resulting from nonspecific electrostatic interactions of cationic guanidino groups and localize in subcytoplasmic organelles.
1 aNanda, Manaswini1 aGanesh, Krishna, N. uhttp://library.ncl.res.in/content/4rs-guanidinylprolyl-collagen-peptides-resin-synthesis-complexation-plasmid-dna-and-role-0