Pd-catalyzed one-pot chemoselective hydrogenation protocol for the preparation of carboxamides directly from azides
| Title | Pd-catalyzed one-pot chemoselective hydrogenation protocol for the preparation of carboxamides directly from azides |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Bavikar, SN, Salunke, DB, Hazra, BG, Pore, VS, Thierry, J, Dodd, RH |
| Journal | Tetrahedron Letters |
| Volume | 51 |
| Issue | 29 |
| Pagination | 3815-3819 |
| Date Published | JUL |
| ISSN | 0040-4039 |
| Keywords | Azide, Carboxamide, Catalytic hydrogenation, Chemoselective, Palladium, Succinimide ester |
| Abstract | Carboxamides were obtained efficiently in high yields from azides on reaction with the corresponding pre-formed activated carboxylic acids in a single-step reductive transformation using hydrogen atmosphere (balloon) under Pd/BaSO(4) or Pd/CaCO(3) catalysis. The method is highly chemoselective and compatible with extremely labile functional groups such as benzyl carbamates, benzyl ethers, benzyl esters, and olefins. (C) 2010 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2010.05.066 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.618 |
Divison category:
Organic Chemistry