%0 Journal Article %J Tetrahedron Letters %D 2010 %T Pd-catalyzed one-pot chemoselective hydrogenation protocol for the preparation of carboxamides directly from azides %A Bavikar, Sudhir N. %A Salunke, Deepak B. %A Hazra, Braja G. %A Pore, Vandana S. %A Thierry, Josiane %A Dodd, Robert H. %K Azide %K Carboxamide %K Catalytic hydrogenation %K Chemoselective %K Palladium %K Succinimide ester %X

Carboxamides were obtained efficiently in high yields from azides on reaction with the corresponding pre-formed activated carboxylic acids in a single-step reductive transformation using hydrogen atmosphere (balloon) under Pd/BaSO(4) or Pd/CaCO(3) catalysis. The method is highly chemoselective and compatible with extremely labile functional groups such as benzyl carbamates, benzyl ethers, benzyl esters, and olefins. (C) 2010 Elsevier Ltd. All rights reserved.

%B Tetrahedron Letters %I PERGAMON-ELSEVIER SCIENCE LTD %C THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND %V 51 %P 3815-3819 %8 JUL %G eng %N 29 %3 Foreign %4 2.618 %R 10.1016/j.tetlet.2010.05.066