Natural gum reduced/stabilized gold nanoparticles for drug delivery formulations

TitleNatural gum reduced/stabilized gold nanoparticles for drug delivery formulations
Publication TypeJournal Article
Year of Publication2008
AuthorsDhar, S, E. Reddy, M, Shiras, A, Pokharkar, V, Prasad, BLV
JournalChemistry-A European Journal
Volume14
Issue33
Pagination10244-10250
Date PublishedOCT
ISSN0947-6539
KeywordsApoptosis, Cytotoxicity, drug delivery, Gold, Nanostructures, natural gums
Abstract

``Gellan Gum'', widely used in food and confectionary industry as a thickening and gelling agent, has been employed as a reducing and stabilizing agent for the synthesis of gold nanoparticles. These nanoparticles display greater stability to electrolyte addition and pH changes relative to the traditional citrate and borohydride reduced nanoparticles. Subsequently these have been used to load anthracycline ring antibiotic doxorubicin hydrochloride. The drug loaded on these nanoparticles showed enhanced cytotoxic effects on human glioma cell lines LN-18 and LN-229.

DOI10.1002/chem.200801093
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)5.476
Divison category: 
Physical and Materials Chemistry