Microwave studies on synthesis of biologically active chalcone derivatives

TitleMicrowave studies on synthesis of biologically active chalcone derivatives
Publication TypeJournal Article
Year of Publication2008
AuthorsKatade, S, Phalgune, U, Biswas, S, Wakharkar, R, Deshpande, N
JournalIndian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry
Volume47
Issue6
Pagination927-931
Date PublishedJUN
ISSN0376-4699
KeywordsAntimicrobial activity, chalcones, Pyrazole
Abstract

Synthesis of pyrazole derivative using microwave energy has been carried out. The compound 1-[4-(2-hydroxy-ethoxy)-phenyl]-ethanone, is prepared from p-hydroxy-acetophenone and 2-chloro-ethanol. Chalcone derivative has been prepared by the condensation reaction of 1-[4-(2-hydroxy-ethoxy)-phenyl]- ethanone with 4-chlorobenzaldehyde. This chalcone. derivative cyclised with hydrazine hydrate and glacial acetic acid under microwave irradiation conditions give pyrazole derivative. These products have been characterized by detailed spectral analysis and have been screened for their antimicrobial activity, against Escherichia coli, Proteus vulgaris, and Salmonella typhimurium.

Type of Journal (Indian or Foreign)Indian
Impact Factor (IF)0.562
Divison category: 
Center for Material Characterization (CMC)