01512nas a2200229 4500008004100000022001400041245007900055210006900134260010300203300001200306490000700318520069000325653002701015653001401042653001301056100002001069700001901089700001901108700002301127700002301150856010901173 2008 eng d a0376-469900aMicrowave studies on synthesis of biologically active chalcone derivatives0 aMicrowave studies on synthesis of biologically active chalcone d aANUSANDHAN BHAWAN, 2 RAFI MARG, NEW DELHI, 110001, INDIAbCOUNCIL SCIENTIFIC & INDUSTRIAL REScJUN a927-9310 v473 a
Synthesis of pyrazole derivative using microwave energy has been carried out. The compound 1-[4-(2-hydroxy-ethoxy)-phenyl]-ethanone, is prepared from p-hydroxy-acetophenone and 2-chloro-ethanol. Chalcone derivative has been prepared by the condensation reaction of 1-[4-(2-hydroxy-ethoxy)-phenyl]- ethanone with 4-chlorobenzaldehyde. This chalcone. derivative cyclised with hydrazine hydrate and glacial acetic acid under microwave irradiation conditions give pyrazole derivative. These products have been characterized by detailed spectral analysis and have been screened for their antimicrobial activity, against Escherichia coli, Proteus vulgaris, and Salmonella typhimurium.
10aAntimicrobial activity10achalcones10aPyrazole1 aKatade, Sushama1 aPhalgune, Usha1 aBiswas, Sujata1 aWakharkar, Radhika1 aDeshpande, Nirmala uhttp://library.ncl.res.in/content/microwave-studies-synthesis-biologically-active-chalcone-derivatives-0