Iridium(III)-catalyzed alkynylation of 2-(Hetero)arylquinazolin-4-one scaffolds via C-H bond activation
| Title | Iridium(III)-catalyzed alkynylation of 2-(Hetero)arylquinazolin-4-one scaffolds via C-H bond activation |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Rohokale, RS, Kalshetti, RG, Ramana, CV |
| Journal | Journal of Organic Chemistry |
| Volume | 84 |
| Issue | 5 |
| Pagination | 2951-2961 |
| Date Published | MAR |
| Type of Article | Article |
| ISSN | 0022-3263 |
| Abstract | The directed C-H alkynylation of 2-(hetero)arylquinazolin-4-ones has been explored with the ethynylbenziodoxolone reagent TIPS-EBX employing an Ir(III) catalyst. Complementary conditions for either monoalkynylation or dialkynylation have been developed. Also demonstrated is the broad scope of this reaction and the compatibility of various functional groups such as -F, -Cl, -Br, -CF3, -OMe, -NO2, and alkyl, etc. |
| DOI | 10.1021/acs.joc.8b02738 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.745 |
Divison category:
Organic Chemistry
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