01068nas a2200169 4500008004100000022001400041245010800055210006900163260000900232300001400241490000700255520042800262100002700690700002600717700002400743856013100767 2019 eng d a0022-326300aIridium(III)-catalyzed alkynylation of 2-(Hetero)arylquinazolin-4-one scaffolds via C-H bond activation0 aIridiumIIIcatalyzed alkynylation of 2Heteroarylquinazolin4one sc cMAR a2951-29610 v843 a
The directed C-H alkynylation of 2-(hetero)arylquinazolin-4-ones has been explored with the ethynylbenziodoxolone reagent TIPS-EBX employing an Ir(III) catalyst. Complementary conditions for either monoalkynylation or dialkynylation have been developed. Also demonstrated is the broad scope of this reaction and the compatibility of various functional groups such as -F, -Cl, -Br, -CF3, -OMe, -NO2, and alkyl, etc.
1 aRohokale, Rajendra, S.1 aKalshetti, Rupali, G.1 aRamana, Chepuri, V. uhttp://library.ncl.res.in/content/iridiumiii-catalyzed-alkynylation-2-heteroarylquinazolin-4-one-scaffolds-c-h-bond-activation