Glycine-linked nucleoside-beta-amino acids: polyamide analogues of nucleic acids
| Title | Glycine-linked nucleoside-beta-amino acids: polyamide analogues of nucleic acids |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Banerjee, A, Bagmare, S, Varada, M, Kumar, VA |
| Journal | Bioconjugate Chemistry |
| Volume | 26 |
| Issue | 8 |
| Pagination | 1737-1742 |
| Date Published | AUG |
| ISSN | 1043-1802 |
| Abstract | 3'-5'-Deoxyribose-sugar-phoshate backbone in DNA is completely replaced by 2'-deoxyribonucleoside-based beta-amino acids interlinked by glycine to create uncharged polyamide DNA with 3'-5'-directionality. These oligomers as conjugates of alpha-amino acids and nucleoside-beta-amino acids bind strongly and sequence-specifically only to the antiparallel complementary RNA and DNA. |
| DOI | 10.1021/acs.bioconjchem.5b00296 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.5 |
Divison category:
Organic Chemistry