Glycine-linked nucleoside-beta-amino acids: polyamide analogues of nucleic acids

TitleGlycine-linked nucleoside-beta-amino acids: polyamide analogues of nucleic acids
Publication TypeJournal Article
Year of Publication2015
AuthorsBanerjee, A, Bagmare, S, Varada, M, Kumar, VA
JournalBioconjugate Chemistry
Volume26
Issue8
Pagination1737-1742
Date PublishedAUG
ISSN1043-1802
Abstract

3'-5'-Deoxyribose-sugar-phoshate backbone in DNA is completely replaced by 2'-deoxyribonucleoside-based beta-amino acids interlinked by glycine to create uncharged polyamide DNA with 3'-5'-directionality. These oligomers as conjugates of alpha-amino acids and nucleoside-beta-amino acids bind strongly and sequence-specifically only to the antiparallel complementary RNA and DNA.

DOI10.1021/acs.bioconjchem.5b00296
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)4.5
Divison category: 
Organic Chemistry