Generation and evaluation of pharmacologically relevant drug-drug cocrystal for gout therapy
| Title | Generation and evaluation of pharmacologically relevant drug-drug cocrystal for gout therapy |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Modani, S, Gunnam, A, Yadav, B, Nangia, AK, Shastri, NR |
| Journal | Crystal Growth & Design |
| Volume | 20 |
| Issue | 6 |
| Pagination | 3577-3583 |
| Date Published | JUN |
| Type of Article | Article |
| ISSN | 1528-7483 |
| Abstract | The present study reports a novel drug-drug cocrystal of febuxostat and piroxicam for the treatment of gout. Single crystal X-ray diffraction revealed a monoclinic system with P2(1)/c space group. The prepared cocrystal enhanced the solubility of febuxostat and piroxicam and improved the dissolution rate of piroxicam in pH 6.8 as compared to the pure drug. Further, the compressibility assessment of cocrystal by Aulton and Wells method confirmed its plastic behavior and suitability for direct compression. |
| DOI | 10.1021/acs.cgd.0c00106 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.089 |
Divison category:
Organic Chemistry
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