01200nas a2200193 4500008004100000022001400041245009700055210006900152260000900221300001400230490000700244520052300251100001900774700002200793700001900815700002400834700002400858856012400882 2020 eng d a1528-748300aGeneration and evaluation of pharmacologically relevant drug-drug cocrystal for gout therapy0 aGeneration and evaluation of pharmacologically relevant drugdrug cJUN a3577-35830 v203 a
The present study reports a novel drug-drug cocrystal of febuxostat and piroxicam for the treatment of gout. Single crystal X-ray diffraction revealed a monoclinic system with P2(1)/c space group. The prepared cocrystal enhanced the solubility of febuxostat and piroxicam and improved the dissolution rate of piroxicam in pH 6.8 as compared to the pure drug. Further, the compressibility assessment of cocrystal by Aulton and Wells method confirmed its plastic behavior and suitability for direct compression.
1 aModani, Sheela1 aGunnam, Anilkumar1 aYadav, Balvant1 aNangia, Ashwini, K.1 aShastri, Nalini, R. uhttp://library.ncl.res.in/content/generation-and-evaluation-pharmacologically-relevant-drug-drug-cocrystal-gout-therapy