First iodocyclization reaction of allene-thioureas: an efficient approach to bicyclic beta-lactams
| Title | First iodocyclization reaction of allene-thioureas: an efficient approach to bicyclic beta-lactams |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Garud, DR, Jadhav, AR, Lahore, SV, Kahar, NM, Joshi, RR, Joshi, RA, Koketsu, M |
| Journal | Tetrahedron Letters |
| Volume | 55 |
| Issue | 43 |
| Pagination | 5998-6000 |
| Date Published | OCT |
| ISSN | 0040-4039 |
| Keywords | Allene, beta-Lactams, Iodocyclization, Regioselective, thiourea |
| Abstract | The regioselective iodocyclization reaction of allene-thioureas is described, for the first time, for the synthesis of bicyclic beta-lactams. The substitution at the allenyl part heavily influenced the iodocyclization reaction. The iodocyclization reaction of the unsubstituted allene-thioureas afforded six-membered 3-thia-1-dethiacephems whereas, the substituted allene-thiourea afforded seven-membered thiazepines along with five-membered isopenams. (C) 2014 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2014.09.004 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.68 |
Divison category:
Organic Chemistry