01502nas a2200277 4500008004100000022001400041245010300055210006900158260010600227300001400333490000700347520050800354653001100862653001700873653002000890653001900910653001300929100002200942700002100964700002400985700002201009700002201031700002201053700002001075856012901095 2014 eng d a0040-403900aFirst iodocyclization reaction of allene-thioureas: an efficient approach to bicyclic beta-lactams0 aFirst iodocyclization reaction of allenethioureas an efficient a aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT a5998-60000 v553 a
The regioselective iodocyclization reaction of allene-thioureas is described, for the first time, for the synthesis of bicyclic beta-lactams. The substitution at the allenyl part heavily influenced the iodocyclization reaction. The iodocyclization reaction of the unsubstituted allene-thioureas afforded six-membered 3-thia-1-dethiacephems whereas, the substituted allene-thiourea afforded seven-membered thiazepines along with five-membered isopenams. (C) 2014 Elsevier Ltd. All rights reserved.
10aAllene10abeta-Lactams10aIodocyclization10aRegioselective10athiourea1 aGarud, Dinesh, R.1 aJadhav, Amol, R.1 aLahore, Santosh, V.1 aKahar, Nilesh, M.1 aJoshi, Rohini, R.1 aJoshi, Ramesh, A.1 aKoketsu, Mamoru uhttp://library.ncl.res.in/content/first-iodocyclization-reaction-allene-thioureas-efficient-approach-bicyclic-beta-lactams-0