Facile enantioselective synthesis of enantiomerically pure (R)-phenoxybenzamine hydrochloride using the hydrolytic kinetic resolution method
| Title | Facile enantioselective synthesis of enantiomerically pure (R)-phenoxybenzamine hydrochloride using the hydrolytic kinetic resolution method |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Nikalje, MD, Sasikumar, M, Muthukrishnan, M |
| Journal | Tetrahedron-Asymmetry |
| Volume | 21 |
| Issue | 23 |
| Pagination | 2825-2829 |
| Date Published | DEC |
| ISSN | 0957-4166 |
| Abstract | A practical and highly efficient enantioselective synthesis of (R)-phenoxybenzamine hydrochloride has been described for the first time using Jacobsen's hydrolytic kinetic resolution of a terminal epoxide as a key step and source of chirality. (C) 2010 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetasy.2010.11.011 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.484 |
Divison category:
Organic Chemistry