Facile and solvent-free domino synthesis of new quinolidinyl-2,4-thiazolidinones: antifungal activityand molecular docking
| Title | Facile and solvent-free domino synthesis of new quinolidinyl-2,4-thiazolidinones: antifungal activityand molecular docking |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Subhedar, DD, Shaikh, MH, Tupe, SG, Deshpande, MV, Khedkar, VM, Jha, PC, Shingate, BB |
| Journal | Mini-Reviews in Medicinal Chemistry |
| Volume | 18 |
| Issue | 7 |
| Pagination | 622-630 |
| Date Published | JAN |
| Abstract | Objective: We have synthesized new quinolidinyl-thiazolidinones via Knoevenagel condensation-alkylation reaction, catalyzed by [Et3NH][HSO4]. The present approach offers several advantages such as higher yields, eco-friendly reaction condition and economic availability of the catalyst. Method: The newly synthesized compounds were evaluated for their in vitro antifungal activity against six fungal strains. Some of the synthesized conjugates displayed good to moderate antifungal activity. Conclusion: Again, the molecular docking study performed against the fungal sterol 14 alpha-demethylase (CYP51) showed an excellent binding affinity towards the enzyme which could rationalize the promising antifungal activity portrayed by these derivatives and provides a platform for structure based drug design. |
| DOI | 10.2174/1389557516666161226161152 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.661 |
Divison category:
Biochemical Sciences