TY - JOUR T1 - Facile and solvent-free domino synthesis of new quinolidinyl-2,4-thiazolidinones: antifungal activityand molecular docking JF - Mini-Reviews in Medicinal Chemistry Y1 - 2018 A1 - Subhedar, Dnyaneshwar D. A1 - Shaikh, Mubarak H. A1 - Tupe, Santosh G. A1 - Deshpande, Mukund V. A1 - Khedkar, Vijay M. A1 - Jha, Prakash C. A1 - Shingate, Bapurao B. AB - Objective: We have synthesized new quinolidinyl-thiazolidinones via Knoevenagel condensation-alkylation reaction, catalyzed by [Et3NH][HSO4]. The present approach offers several advantages such as higher yields, eco-friendly reaction condition and economic availability of the catalyst. Method: The newly synthesized compounds were evaluated for their in vitro antifungal activity against six fungal strains. Some of the synthesized conjugates displayed good to moderate antifungal activity. Conclusion: Again, the molecular docking study performed against the fungal sterol 14 alpha-demethylase (CYP51) showed an excellent binding affinity towards the enzyme which could rationalize the promising antifungal activity portrayed by these derivatives and provides a platform for structure based drug design. VL - 18 IS - 7 U3 - Foreign U4 - 2.661 ER -