Efforts to access the potent antitrypanosomal marine natural product janadolide: synthesis of des- tert -butyl janadolide and its biological evaluation
| Title | Efforts to access the potent antitrypanosomal marine natural product janadolide: synthesis of des- tert -butyl janadolide and its biological evaluation |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Athawale, PR, Jachak, G, Shukla, A, Shanmugam, D, Reddy, S |
| Journal | ACS Omega |
| Date Published | FEB |
| Abstract | To identify novel antitrypanosomal agents based on Janadolide, a potent macrocyclic polyketide–peptide hybrid, a macrolactonization strategy was explored. We prepared des-tert-butyl Janadolide and evaluated its antitrypanosomal activity. Our findings suggest that the tert-butyl group is necessary for the desired bioactivity. |
| DOI | 10.1021/acsomega.7b01920 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | Not Available |
Divison category:
Biochemical Sciences
Organic Chemistry