%0 Journal Article %J ACS Omega %D 2018 %T Efforts to access the potent antitrypanosomal marine natural product janadolide: synthesis of des- tert -butyl janadolide and its biological evaluation %A Athawale, Paresh R. %A Jachak, Gorakh %A Shukla, Anurag %A Shanmugam, Dhanasekaran %A Reddy, Srinivasa %X To identify novel antitrypanosomal agents based on Janadolide, a potent macrocyclic polyketide–peptide hybrid, a macrolactonization strategy was explored. We prepared des-tert-butyl Janadolide and evaluated its antitrypanosomal activity. Our findings suggest that the tert-butyl group is necessary for the desired bioactivity. %B ACS Omega %8 FEB %G eng %3 Foreign %4 Not Available %R 10.1021/acsomega.7b01920