Diastereoselective synthesis of chiral 2,3-disubstituted lndolines via formal [3+2]-cycloaddition of arynes with gamma-amino-alpha,beta-unsaturated esters

TitleDiastereoselective synthesis of chiral 2,3-disubstituted lndolines via formal [3+2]-cycloaddition of arynes with gamma-amino-alpha,beta-unsaturated esters
Publication TypeJournal Article
Year of Publication2017
AuthorsAher, RD, Suryavanshi, GM, Sudalai, A
JournalJournal of Organic Chemistry
Volume82
Start Page5940-5946
Issue11
Pagination5940-5946
Date PublishedJUN
ISSN0022-3263
AbstractA one step formal [3+2]-annulation protocol for the synthesis of 2,3-disubstituted indolines is described. The in situ generated aryne acts as a two-atom component, and gamma-amino-alpha,beta-unsaturated esters acting as a three-atom component to construct indoline units in a highly regio- and diastereoselective manner with yields ranging from 63 to 80%.
DOI10.1021/acs.joc.7b00439
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)4.785
Divison category: 
Chemical Engineering & Process Development

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