Cyanuryl peptide nucleic acid: synthesis and DNA complexation properties
| Title | Cyanuryl peptide nucleic acid: synthesis and DNA complexation properties |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Vysabhattar, R, Ganesh, KN |
| Journal | Tetrahedron Letters |
| Volume | 49 |
| Issue | 8 |
| Pagination | 1314-1318 |
| Date Published | FEB |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Keywords | cyanuryl PNA, PNA |
| Abstract | The synthesis of cyanuryl PNA monomer (CyaPNA) 6 was achieved by direct N-monoalkylation of cyanuric acid with N-(2-Boc-aminoethyl)-N'-(bromoacetyl)glycyl ethyl ester 4. Compound 6 was incorporated as a T-mimic into PNA oligomers and biophysical studies on their triplexes/duplex complexes with complementary DNA oligomers indicated unusual stabilization of PNA:DNA hybrids when the cyanuryl unit was located in the middle of the PNA oligomer. (c) 2008 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2007.12.095 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Organic Chemistry