@article { ISI:000253646700006, title = {Cyanuryl peptide nucleic acid: synthesis and DNA complexation properties}, journal = {Tetrahedron Letters}, volume = {49}, number = {8}, year = {2008}, month = {FEB}, pages = {1314-1318}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {
The synthesis of cyanuryl PNA monomer (CyaPNA) 6 was achieved by direct N-monoalkylation of cyanuric acid with N-(2-Boc-aminoethyl)-N{\textquoteright}-(bromoacetyl)glycyl ethyl ester 4. Compound 6 was incorporated as a T-mimic into PNA oligomers and biophysical studies on their triplexes/duplex complexes with complementary DNA oligomers indicated unusual stabilization of PNA:DNA hybrids when the cyanuryl unit was located in the middle of the PNA oligomer. (c) 2008 Elsevier Ltd. All rights reserved.
}, keywords = {cyanuryl PNA, PNA}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2007.12.095}, author = {Vysabhattar, Raman and Ganesh, Krishna N.} }