Crystalline xylitol production from corncob biomass with oral toxicity analysis
Title | Crystalline xylitol production from corncob biomass with oral toxicity analysis |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Ahuja, V, Dasgupta, D, Kshirsagar, S, Ghosh, P, More, S, Gupta, P, Behera, B, Bhaskar, T |
Journal | Industrial Crops and Products |
Volume | 187 |
Issue | 8 |
Pagination | 115407 |
Date Published | NOV |
Type of Article | Article |
ISSN | 0926-6690 |
Keywords | Biomass, Fermentation, Oral toxicity analysis, Wastewater treatment, xylitol |
Abstract | Xylitol, a five-carbon sugar alcohol, has a steady global market and finds application as a natural sugar substitute in various food and confectionery products. Biocatalytic xylitol production, although touted as a greener alternative to conventional chemical catalysis, suffers from certain challenges, the primary being high cost of production. This study demonstrates a process for food-grade xylitol production from corncob biomass with energy reduction through two major process modifications. A non-conventional fermentation strategy was adopted whereby adjusting aeration without agitation, xylitol with high yield (0.86 +/- 0.015 g/g), and productivity (0.74 gL(-1)h(-1)) could be produced by a GRAS Pichia caribbica MTCC 5703 strain. Xylitol was recovered from the broth in the form of crystals using a combination of membrane-based filtration and crystallization. The crystals demonstrated similar to 98 % purity when quantified with H-1 NMR. Oral toxicity analysis of the crystals demonstrated no adverse effect in female Winstar rats (at a loading of 2000 mg/kg body weight of animals). Overall process statistics showed that 0.584 kg of food-grade xylitol crystals could be produced from 3.5 kg of corncob biomass. The two-process modifications during fermentation and xylitol recovery enabled an energy saving of similar to 20.842 kW/kg of crystals, providing tremendous advantages for biorefinery-based large-scale xylitol production from corncob biomass. |
DOI | 10.1016/j.indcrop.2022.115407 |
Type of Journal (Indian or Foreign) | Foreign |
Impact Factor (IF) | 6.449 |
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