Crystalline xylitol production from corncob biomass with oral toxicity analysis

TitleCrystalline xylitol production from corncob biomass with oral toxicity analysis
Publication TypeJournal Article
Year of Publication2022
AuthorsAhuja, V, Dasgupta, D, Kshirsagar, S, Ghosh, P, More, S, Gupta, P, Behera, B, Bhaskar, T
JournalIndustrial Crops and Products
Volume187
Issue8
Pagination115407
Date PublishedNOV
Type of ArticleArticle
ISSN0926-6690
KeywordsBiomass, Fermentation, Oral toxicity analysis, Wastewater treatment, xylitol
Abstract

Xylitol, a five-carbon sugar alcohol, has a steady global market and finds application as a natural sugar substitute in various food and confectionery products. Biocatalytic xylitol production, although touted as a greener alternative to conventional chemical catalysis, suffers from certain challenges, the primary being high cost of production. This study demonstrates a process for food-grade xylitol production from corncob biomass with energy reduction through two major process modifications. A non-conventional fermentation strategy was adopted whereby adjusting aeration without agitation, xylitol with high yield (0.86 +/- 0.015 g/g), and productivity (0.74 gL(-1)h(-1)) could be produced by a GRAS Pichia caribbica MTCC 5703 strain. Xylitol was recovered from the broth in the form of crystals using a combination of membrane-based filtration and crystallization. The crystals demonstrated similar to 98 % purity when quantified with H-1 NMR. Oral toxicity analysis of the crystals demonstrated no adverse effect in female Winstar rats (at a loading of 2000 mg/kg body weight of animals). Overall process statistics showed that 0.584 kg of food-grade xylitol crystals could be produced from 3.5 kg of corncob biomass. The two-process modifications during fermentation and xylitol recovery enabled an energy saving of similar to 20.842 kW/kg of crystals, providing tremendous advantages for biorefinery-based large-scale xylitol production from corncob biomass.

DOI10.1016/j.indcrop.2022.115407
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

6.449

Divison category: 
Biochemical Sciences
Database: 
Web of Science (WoS)

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