Convenient synthesis of enantiomerically pure (R)-mexiletine using hydrolytic kinetic resolution method
| Title | Convenient synthesis of enantiomerically pure (R)-mexiletine using hydrolytic kinetic resolution method |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Sasikumar, M, Nikalje, MD, Muthukrishnan, M |
| Journal | Tetrahedron-Asymmetry |
| Volume | 20 |
| Issue | 24 |
| Pagination | 2814-2817 |
| Date Published | DEC |
| ISSN | 0957-4166 |
| Abstract | Enantiopure (R)-mexiletine was prepared in a simple and practical way using hydrolytic kinetic resolution method of terminal epoxide by Jacobsen catalyst. High enantiomeric purity (98% ee) was achieved and the method is well amenable to industrial scale-up. (C) 2009 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetasy.2009.11.014 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.484 |
Divison category:
Organic Chemistry