Convenient synthesis of enantiomerically pure (R)-mexiletine using hydrolytic kinetic resolution method

TitleConvenient synthesis of enantiomerically pure (R)-mexiletine using hydrolytic kinetic resolution method
Publication TypeJournal Article
Year of Publication2009
AuthorsSasikumar, M, Nikalje, MD, Muthukrishnan, M
JournalTetrahedron-Asymmetry
Volume20
Issue24
Pagination2814-2817
Date PublishedDEC
ISSN0957-4166
Abstract

Enantiopure (R)-mexiletine was prepared in a simple and practical way using hydrolytic kinetic resolution method of terminal epoxide by Jacobsen catalyst. High enantiomeric purity (98% ee) was achieved and the method is well amenable to industrial scale-up. (C) 2009 Elsevier Ltd. All rights reserved.

DOI10.1016/j.tetasy.2009.11.014
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)2.484
Divison category: 
Organic Chemistry