TY - JOUR T1 - Convenient synthesis of enantiomerically pure (R)-mexiletine using hydrolytic kinetic resolution method JF - Tetrahedron-Asymmetry Y1 - 2009 A1 - Sasikumar, Murugesan A1 - Nikalje, Milind D. A1 - Muthukrishnan, Murugan AB -

Enantiopure (R)-mexiletine was prepared in a simple and practical way using hydrolytic kinetic resolution method of terminal epoxide by Jacobsen catalyst. High enantiomeric purity (98% ee) was achieved and the method is well amenable to industrial scale-up. (C) 2009 Elsevier Ltd. All rights reserved.

PB - PERGAMON-ELSEVIER SCIENCE LTD CY - THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND VL - 20 IS - 24 U3 - Foreign U4 - 2.484 ER -