Construction of tetrahydrobenzo[f]quinoline scaffolds via polar [4+2]-Cycloaddition reaction with arynes as dienophiles
| Title | Construction of tetrahydrobenzo[f]quinoline scaffolds via polar [4+2]-Cycloaddition reaction with arynes as dienophiles |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Pandya, VG, Mhaske, SB |
| Journal | Tetrahedron Letters |
| Volume | 101 |
| Pagination | 153901 |
| Date Published | JUL |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Keywords | Aryne, Diels-Alder, Diene, Tetrahydrobenzo[ f ]quinoline |
| Abstract | A transition-metal-free route has been developed for the direct synthesis of biologically significant tetrahydrobenzo[f]quinoline scaffolds. The reaction features polar [4 + 2] Diels-Alder cycloaddition reaction of arynes with a well-designed diene N-Boc protected vinyl tetrahydropyridine, followed by the isomerisation of the double bond leading to the formation of tetrahydrobenzo[f]quinoline scaffolds in good to moderate yields. |
| DOI | 10.1016/j.tetlet.2022.153901 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.032 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)